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Once-daily GLP-1 weight-loss tablet · MHRA-licensed
Wegovy®
A once-daily tablet for
weight management in adults
GPhC-Regulated PharmacyRegistered with the General Pharmaceutical Council
100% UK-Licensed PrescriptionsAll medicines hold an MHRA licence
Fast & Discreet DeliverySent in plain, unbranded packaging
Weight Loss · Obesity
Wegovy® Pill (oral semaglutide)
£107.00
CategoryWeight Loss (Obesity)
FormTablets · 30-day supply
ActiveSemaglutide (GLP-1)
StorageRoom temperature · no fridge required
1.5mg4mg9mg25mg
1 Pack — 30 tablets ▾
Start online consultation✓ UK-registered pharmacy✓ Discreet Royal Mail delivery✓ Clinician-reviewed
Why the Wegovy® pill
Four reasons patients choose the tablet.
Figures are trial averages · individual results vary
~16.6%average body-weight loss
At the 25mg daily dose over 64 weeks in the OASIS 4 trial, among participants who stayed on treatment as prescribed. Across all participants, including those who stopped early, the average was 13.6%.
OASIS 4 (NEJM, 2025) · trial-product estimand
Needle-free weight loss treatment
Clinically proven semaglutide in a tablet you swallow. No pens, no needles, no injection-site reactions — a proven option for anyone who would rather not inject.
MHRA licence, June 2026
One daily pill, taken each morning
Taken first thing on an empty stomach with a sip of water, then wait 30 minutes before eating or drinking. A simple routine that becomes second nature within days.
Wegovy® tablet SmPC, section 4.2
No fridge required, store at room temperature
Stored at room temperature in its original blister pack. Easy to keep at home, in a bag or when travelling — no cold chain to manage.
Wegovy® tablet SmPC, section 6.4
How it works
Wegovy® is a weight-management treatment for adults living with obesity, or overweight with a weight-related health condition. It works with your body’s own appetite signals to reduce hunger and help you eat less.
Semaglutide is a GLP-1 receptor agonist — it mimics a natural gut hormone released after eating. It acts on appetite centres in the brain to increase fullness and reduce cravings, and slows how quickly the stomach empties. The result: you feel satisfied with smaller portions. Taken once daily, alongside a reduced-calorie diet and more physical activity.
Reduces appetite
Acts on the brain’s appetite centres so you feel full sooner.
Slows stomach emptying
Food stays in your stomach longer, helping fullness last.
Once daily, no needle
One tablet each morning on an empty stomach with plain water.
Is Wegovy® right for you?
Wegovy® is a prescription weight-management medicine, used alongside diet and exercise — not a quick fix. A quick check before you start your consultation.
Check your eligibility- ✓ You are an adult (18+) living in the UK.
- ✓ Your BMI is 30 or above — or 27+ with a weight-related condition such as high blood pressure or type 2 diabetes.
- ✓ You are ready to make diet and activity changes alongside treatment.
Your dosing journey
A gradual build-up, exactly as licensed.
The Wegovy® pill starts at 1.5mg once daily and increases in steps, with a minimum of one month at each dose level. This gradual build-up gives your body time to adjust and keeps side effects manageable. Most patients reach the 25mg maintenance dose at around three months, and your prescriber can hold you at a lower dose for longer if that suits you better.
Month 1Month 2Month 3Month 4+
1.5mg
starting dose4mg
step up9mg
step up25mg
maintenance doseEach tablet is taken first thing in the morning on an empty stomach with no more than 120ml of plain water, then at least 30 minutes before eating, drinking anything else or taking other medicines. Doses are only increased if you are tolerating treatment well. The schedule follows the UK Summary of Product Characteristics.
The clinical evidence
What the OASIS 4 trial showed
In the Phase 3 OASIS 4 trial, adults with overweight or obesity who took the 25mg Wegovy tablet once daily alongside lifestyle changes lost an average of 16.6% of their body weight over 64 weeks while on treatment as prescribed, compared with 2.7% on placebo.
-16.6%
Average body-weight loss while on treatment (trial-product estimand) vs -2.7% on placebo-13.6%
Average across all participants, including those who stopped early (treatment-policy estimand) vs -2.2%79.2%
Of people lost 5% or more of their body weightMean body-weight reduction over time — Wegovy® tablet 25mg, 64 weeks
Source: Aronne LJ et al., OASIS 4, NEJM 2025. Trial-product estimand = weight loss if everyone took the medicine as prescribed for the full trial; treatment-policy estimand = all participants regardless of adherence. Individual results vary.
Wegovy® tablet vs placebo
Both groups followed the same reduced-calorie diet and activity plan — only the active medicine differed.
Placebo + lifestyle
-2.7%body weight
lost
lost
Wegovy® tablets + lifestyle
-16.6%body weight
lost
lost
That’s around 6× more weight lost than diet and exercise alone — for someone weighing 100kg, roughly 16–17kg on average.
OASIS 4, 64 weeks, trial-product estimand (Aronne et al., 2025). Rings are drawn on a 0–28% scale and are illustrative. Weight loss depends on dose, adherence and lifestyle; not everyone responds the same way.
Safety at a glance
Semaglutide has one of the best-documented safety records of any weight-loss medicine, built on more than a decade of clinical use. Most side effects are gastrointestinal, mild to moderate, and ease as your body adjusts to each dose. For a full list of side effects, please see the patient information leaflet.
Eat smaller, lower-fat meals and stay well hydrated to ease nausea, which usually settles within a few weeks of each dose change. Wegovy must not be used in pregnancy and should be stopped at least two months before trying to conceive. Seek urgent medical help for severe or persistent abdominal pain, ongoing vomiting or signs of dehydration. Your medical history and current medicines are always reviewed by a prescriber before treatment begins.
Report a side effect. You can report any suspected side effect from any medicine directly to the MHRA Yellow Card scheme.
Why choose Cuva Health?
UK-regulated prescribing
Fast online consultation
Discreet delivery
Human support via WhatsApp
Registered Pharmacy GPhC 9012581Superintendent Pharmacist Irfan Mahmud — GPhC 2080386Discreet delivery by Royal Mail
Frequently AskedQuestions
What is the Wegovy® pill?
The Wegovy® pill is a once-daily tablet containing semaglutide, a GLP-1 receptor agonist. It is a prescription-only medicine for weight management in adults living with obesity, or overweight with a weight-related health condition, used alongside diet and exercise.
How much weight could I expect to lose?
In the OASIS 4 clinical trial, people taking the 25 mg Wegovy tablet as prescribed lost an average of 16.6% of their body weight over 64 weeks.
For example, a person weighing 100 kg could lose approximately 16.6 kg, bringing their weight to around 83.4 kg.
Individual results may vary.
For example, a person weighing 100 kg could lose approximately 16.6 kg, bringing their weight to around 83.4 kg.
Individual results may vary.
Am I eligible to start Wegovy® tablets?
You may be eligible if you are an adult (18+) in the UK with a BMI of 30 or above, or a BMI of 27 or above with a weight-related condition such as high blood pressure, raised cholesterol or type 2 diabetes. Eligibility is always confirmed through an online clinical consultation and pharmacist review.
How and when should I take it?
Take one tablet each morning on an empty stomach, swallowed whole with a sip of plain water (no more than 120ml). Then wait at least 30 minutes before eating, drinking anything else, or taking other medicines. Taking it correctly is important — food and other drinks reduce how well it is absorbed.
Does the Wegovy® pill need to be kept in the fridge?
No. Wegovy tablets are stored at room temperature in their original blister pack, away from moisture and direct heat. There is no cold chain to manage, which makes them easy to keep at home, in a bag or when travelling.
Why does the dose start low and increase?
Starting at a low dose and increasing it gradually over about 12 weeks helps your body get used to the medicine and significantly reduces gastrointestinal side effects like nausea. Never increase your dose faster than prescribed.
What are the most common side effects?
The most common side effects are gastrointestinal: nausea, diarrhoea, vomiting, constipation and stomach discomfort. They are usually mild to moderate, most noticeable when increasing the dose, and tend to settle over time. Eating smaller meals and staying hydrated can help.
Are there any foods, drinks or medicines to be careful with?
Take it only with plain water and keep other food, drink and medicines at least 30 minutes apart. Avoid alcohol excess, which can worsen stomach side effects. Tell your prescriber about all medicines you take — especially insulin or other diabetes medicines, as your doses may need adjusting.
What happens if I miss a dose?
If you miss a dose, skip it and take your next tablet at your usual time the following morning. Do not take two tablets in one day to make up for a missed dose. If you miss doses for more than a few days, contact your clinician, as you may need to restart at a lower dose.
Will I regain weight if I stop?
Wegovy® supports weight loss while you take it. As with most weight-management medicines, some weight regain is possible after stopping, especially without ongoing lifestyle changes. That’s why it’s used long-term with regular reviews, and alongside sustainable changes to diet and activity that you can maintain.
Sources
- Aronne LJ et al. — Oral Semaglutide 25 mg in Adults with Overweight or Obesity (OASIS 4), NEJM 2025
- MHRA / GOV.UK — First GLP-1 tablet for weight loss approved in the UK, 11 June 2026
- emc — Wegovy® tablets Summary of Product Characteristics (sections 4.2, 6.4)
- MHRA — Yellow Card scheme