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The first GLP-1 weight-loss pill
Wegovy®
A once-daily tablet for
weight management in adults
GPhC-Regulated PharmacyRegistered with the General Pharmaceutical Council
100% UK-Licensed PrescriptionsAll medicines hold an MHRA licence
Fast & Discreet DeliverySent in plain, unbranded packaging
Weight Loss · Obesity
Wegovy® (oral semaglutide)
£229.00£199.00Save £30
CategoryWeight Loss (Obesity)
FormFilm-coated tablet · 30-day supply
ActiveSemaglutide (GLP-1)
25mg14mgTitration pack
Start online consultation✓ UK-registered pharmacy✓ Discreet Royal Mail delivery✓ Clinician-reviewed
How it works
Wegovy® is a weight-management treatment for adults living with obesity, or overweight with a weight-related health condition. It works with your body's own appetite signals to reduce hunger and help you eat less.
Semaglutide is a GLP-1 receptor agonist — it mimics a natural gut hormone released after eating. It acts on appetite centres in the brain to increase fullness and reduce cravings, and slows how quickly the stomach empties. The result: you feel satisfied with smaller portions. Taken once daily, alongside a reduced-calorie diet and more physical activity.
Reduces appetite
Acts on the brain's appetite centres so you feel full sooner.
Slows stomach emptying
Food stays in your stomach longer, helping fullness last.
Once daily, no needle
One tablet each morning on an empty stomach with plain water.
Is Wegovy® right for you?
Wegovy® is a prescription weight-management medicine, used alongside diet and exercise — not a quick fix. A quick check before you start your consultation.
Check your eligibility- ✓ You are an adult (18+) living in the UK.
- ✓ Your BMI is 30 or above — or 27+ with a weight-related condition such as high blood pressure or type 2 diabetes.
- ✓ You are ready to make diet and activity changes alongside treatment.
The Cuva Health treatment timeline
Weeks 1–12 · Building up your dose
You start on a low dose and increase it in steps roughly every 4 weeks. This gradual build-up gives your body time to adjust and keeps side effects like nausea to a minimum. Take one tablet each morning on an empty stomach, with no more than 120ml of plain water, then wait at least 30 minutes before eating, drinking anything else, or taking other medicines.
On your maintenance dose
Once you reach your target dose (up to 25mg), appetite reduction and steady weight loss typically continue over the following months. Wegovy works best alongside a reduced-calorie diet and regular activity — it makes those changes easier to stick to, rather than replacing them. Keep your daily routine consistent for the best results.
Ongoing reviews
Your progress is reviewed regularly. If the treatment is helping you lose weight and you're tolerating it well, it can be continued long-term with supervision. If you're not seeing enough benefit, your clinician will discuss adjusting the dose or stopping. Weight management is a long-term journey — reviews keep your plan on track.
The clinical evidence
What the clinical evidence shows
In the Phase 3 OASIS 4 trial (Garvey et al., 2024), adults with overweight or obesity who took oral semaglutide 25mg alongside lifestyle changes lost significantly more weight than those on placebo — over 64 weeks.
-13.6%
Average body-weight reduction vs -2.2% on placebo79.2%
Of people lost 5% or more of their body weightComparable
Weight loss similar to injectable semaglutide 2.4mgMean body-weight reduction over time vs placebo — oral semaglutide 25mg (treatment-policy estimate)
Source: Garvey WT et al., OASIS 4, 2024 (treatment-policy analysis). On-treatment weight loss was -16.6%. Individual results vary.
Oral semaglutide vs placebo at 64 weeks
Average share of starting body weight lost. Both groups followed the same reduced-calorie diet and activity plan — only the active medicine differed.
That's around 6× more weight lost than diet and exercise alone — for someone weighing 100kg, roughly 13–14kg on average.
OASIS 4, 64 weeks, treatment-policy analysis (Garvey et al., 2024). Conic charts are illustrative. Weight loss depends on dose, adherence and lifestyle; not everyone responds the same way.
Tablet vs injection — how do they compare?
An honest look at oral semaglutide tablets versus the weekly Wegovy® injection.
| Wegovy® tablets (oral) | Wegovy® injection (weekly) | |
|---|---|---|
| Active ingredient | Semaglutide | Semaglutide |
| How you take it | One tablet, once daily — no needle | One injection, once weekly |
| Average weight loss | ~13.6% over 64 weeks | ~15% over 68 weeks (STEP 1) |
| Daily routine | Empty stomach, plain water, wait 30 min | Any time, with or without food |
| Storage | Room temperature | Refrigerated before first use |
| Best for | People who prefer pills to needles | People who prefer once-weekly dosing |
How long is it designed to be used?
Weight management is a long-term commitment — these are maintenance treatments, not short courses.
Dose escalation (build-up)
Ongoing maintenance & review
The dose is increased gradually to reduce side effects. Treatment is reviewed regularly and continued only if it's helping. Always follow your prescriber's advice.
Safety at a glance
How often side effects occur, by frequency band. Most are gastrointestinal, mild to moderate, and ease as your body adjusts to the dose.
Commonmore than 1 in 10 people
Nausea · diarrhoea · vomiting · constipation · stomach pain · tiredness
Less commonup to 1 in 100 people
Gallstones · dehydration · raised heart rate · gallbladder inflammation
Eat smaller meals and stay hydrated to ease nausea, which usually settles. Seek urgent help for severe, persistent stomach pain (a rare sign of pancreatitis). Not for use in pregnancy. Report side effects via the MHRA Yellow Card scheme: yellowcard.mhra.gov.uk.
Why choose Cuva Health?
UK-regulated prescribing
Fast online consultation
Discreet delivery
Human support via WhatsApp
Frequently AskedQuestions
What is Wegovy® in tablet form?
Wegovy® tablets contain semaglutide — the same active ingredient as the well-known weekly Wegovy injection — in a once-daily pill. It is a prescription-only medicine for weight management in adults living with obesity, or overweight with a weight-related health condition, used alongside diet and exercise.
How is it different from the Wegovy injection?
Both contain semaglutide and work the same way. The key difference is how you take them: the tablet is swallowed once a day with no needle, while the injection is given once a week. In clinical trials, oral semaglutide 25mg produced weight loss broadly comparable to injectable semaglutide.
How much weight could I expect to lose?
In the Phase 3 OASIS 4 trial, adults taking oral semaglutide 25mg lost an average of 13.6% of their body weight over 64 weeks, compared with 2.2% on placebo — and around 79% lost at least 5% of their weight. Results vary from person to person and depend on dose, adherence and lifestyle changes.
Am I eligible to start Wegovy® tablets?
You may be eligible if you are an adult (18+) in the UK with a BMI of 30 or above, or a BMI of 27 or above with a weight-related condition such as high blood pressure, raised cholesterol or type 2 diabetes. Eligibility is always confirmed through an online clinical consultation and pharmacist review.
How and when should I take it?
Take one tablet each morning on an empty stomach, swallowed whole with a sip of plain water (no more than 120ml). Then wait at least 30 minutes before eating, drinking anything else, or taking other medicines. Taking it correctly is important — food and other drinks reduce how well it is absorbed.
Why does the dose start low and increase?
Starting at a low dose and increasing it gradually over about 12 weeks helps your body get used to the medicine and significantly reduces gastrointestinal side effects like nausea. Never increase your dose faster than prescribed.
What are the most common side effects?
The most common side effects are gastrointestinal: nausea, diarrhoea, vomiting, constipation and stomach discomfort. They are usually mild to moderate, most noticeable when increasing the dose, and tend to settle over time. Eating smaller meals and staying hydrated can help.
Are there any foods, drinks or medicines to be careful with?
Take it only with plain water and keep other food, drink and medicines at least 30 minutes apart. Avoid alcohol excess, which can worsen stomach side effects. Tell your prescriber about all medicines you take — especially insulin or other diabetes medicines, as your doses may need adjusting.
What happens if I miss a dose?
If you miss a dose, skip it and take your next tablet at your usual time the following morning. Do not take two tablets in one day to make up for a missed dose. If you miss doses for more than a few days, contact your clinician, as you may need to restart at a lower dose.
Will I regain weight if I stop?
Wegovy® supports weight loss while you take it. As with most weight-management medicines, some weight regain is possible after stopping, especially without ongoing lifestyle changes. That's why it's used long-term with regular reviews, and alongside sustainable changes to diet and activity that you can maintain.